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Thrombophilia in non varicose veins

  • 06
    Dr Gabriella Lucchi and colleagues from the J. F. Merlen Research Center for Vascular Diseases, Frosinone, Italy have investigated the prevalence of thrombophilic disorders in patients with non varicose vein thrombophlebitis.

    An observational study was conducted on 73 consecutive superficial vein thrombosis patients tested for inherited or acquired thrombophilia.

    The researchers found that 46 of 60 patients were found to have a thrombophilia (76.6%).

    The types detected were:

    factor V Leiden (31/60, i.e. 51.6%)

    prothrombin mutation (2/60, i.e. 3.3%)

    MTHFR mutation (23/60, i.e. 38.3%)

    antiphospholipid antibodies (5/60, i.e. 8.3%)

    protein C deficiency (1/60, i.e. 1.6%)

    protein S deficiency (1/60, i.e. 1.6%)

    antithrombin deficiency (0/60, i.e. 0%)

    The authors concluded from this semina study that "Among patients with superficial vein thrombosis in non-varicose veins, testing demonstrated a high prevalence of thrombophilia. The most common form proved to be factor V Leiden.

    Lucchi G, Bilancini S, Tucci S and Lucchi M.  Superficial vein thrombosis in non-varicose veins of the lower limbs asnd thrombophilia.   Phlebology 2018; 33:  278-281. 

    Dr Karamanoukian's comment;  FV Leiden is the most common inherited disorder in Caucasian people with an incidence of 1 in 5,000 in the population.