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Factor V Leiden mutation in venous ulcers

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    What is post thrombotic syndrome ?  

    Venous insufficiency following deep venous thrombosis is known as the post thrombotic syndrome. Whilst its presentation and symptoms can vary slightly between individuals, it can have a profound effect on quality of life. Symptoms range from mild limb swelling to severe intractable ulceration. 

    Dr Hafner and colleagues have investigated the prevalence of factor V Leiden mutation in patients with postthrombotic and non-postthrombotic venous ulcers.

    The study was conducted at the Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland. 

    In postthrombotic ulcers, the prevalence of the factor V Leiden mutation was 38%

    In non-postthrombotic venous ulcers, the prevalence was 16%.

    As such, the authors concluded that "the factor V Leiden mutation is highly prevalent in patients with postthrombotic venous ulcers. Even patients with non-postthrombotic venous ulcers show a moderately elevated prevalence of the factor V Leiden mutation". 

    Hafner J, Kuhne A, Schlar B, Bombeli T, Hauser M, Luthi R, Hanseler E.   aFactor V Leiden mutation in postthrombotic and non-postthrombotic venous ulcers. Arch Dermatol 2001; 137:  599-603.