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Prevalence of thrombophilia in the general population

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    By Katherine Kozlowski (Medical Writer and Contributor to Vein News and VeinsVeinsVens.com)

    What is the prevalence of the most common thrombophlia mutations ?

    The most common thrombophilic disorder is the heterozygous factor V Leiden mutation, occurring in approximately 5% of pateints of northern European descent. 

    The prevalence of prothrombin gene mutation ranges from 0 to 4.7% of asymptomatic individuals.

    Deficiencies of protein C and S are found in <1% of asymptomatic individuals. 

    Nicholson M, Chan N, Bhagirath V and Ginsberg J. Prevention of Venous Thromboembolism in 2020 and Beyond.  J CLin Med 2020; 9(8): 2467.

    Dr Karamanoukian's comment:  patients who have had recurrent episodes of deep vein throbosis are considered for genetic testing on a case by case basis.  These genetic tests are ordered after consultation with a hematologist.